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Article

Prodrug-activated gene therapy: involvement of an immunological component in the "bystander effect".

Cancer gene therapy - 1 Jan 2000

Gagandeep S, Brew R, Green B, Christmas S E, Klatzmann D, Poston G J, Kinsella A R

Abstract excerpt

The integration and expression of the herpes simplex virus type 1 thymidine kinase (HSV1-TK) gene in localized tumors results in tumor regression after the administration of the specific nucleoside analogue ganciclovir (GCV). Although only 10% to 20% of the tumor cells take up the HSV1-TK gene, the neighboring cells also die, a phenomenon termed "bystander effect.". In the present study, coinjection of the MC26...

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PMID: 8729906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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