Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype.

doi:10.1016/j.clinbiochem.2007.06.003

Article

Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype.

Clinical biochemistry - 1 Oct 2007

Zatterale Adriana, Kelly Frank J, Degan Paolo, d'Ischia Marco, Pallardó Federico V, Calzone Rita, Dunster Christina, Lloret Ana, Manini Paola, Coğulu Ozgur, Kavakli Kaan, Pagano Giovanni

Abstract excerpt

OBJECTIVE: To evaluate an association of Bloom syndrome (BS) phenotype with an in vivo prooxidant state. METHODS: The following endpoints were measured in 4 BS patients, their 6 parents, and 78 controls: a) leukocyte and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG); b) blood glutathione (GSSG and GSH), c) plasma levels of some plasma antioxidants (uric acid, UA, ascorbic acid, AA, alpha- and gamma-tocopherol),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Oxidative stress biomarkers in four Bloom syndrome (BS) patients and in their parents suggest in vivo redox abnormalities in BS phenotype.

Abstract excerpt

Topics

Related research