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Article

Coenzyme Q<sub>10</sub> and oxidative imbalance in Down syndrome: Biochemical and clinical aspects

1 Jan 2008

Abstract excerpt

Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with mental retardation and Alzheimer-like dementia, characteristic change of the individual's phenotype and premature ageing. Oxidative stress is known to play a major role in this pathology since a gene dose effect leads to elevated ratio of superoxide dismutase to catalase/glutathione peroxidase compared to controls in all age categories...

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PMID: 19096112
DOI: 10.1002/biof.5520320119

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