Article
Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori.
Genetical research - 1 Apr 2007
Sandrelli Federica, Cappellozza Silvia, Benna Clara, Saviane Alessio, Mastella Antonio, Mazzotta Gabriella M, Moreau Stephane, Pegoraro Mirko, Piccin Alberto, Zordan Mauro A, Cappellozza Luciano, Kyriacou Charalambos P, Costa Rodolfo
Abstract excerpt
The lepidopteran Bombyx mori is an insect of considerable scientific and economic importance. Recently, the B. mori circadian clock gene period has been molecularly characterized. We have transformed a B. mori strain with a construct encoding a period double-strand RNA in order to knock-down period gene expression. We observe that this post-transcriptional silencing produces a small but detectable disruption in...
Topics
- Animals
- Animals, Genetically Modified
- Bombyx
- Circadian Rhythm
- Female
- Gene Expression Regulation, Developmental
- Life Cycle Stages
- Male
- Nuclear Proteins
- Period Circadian Proteins
- Phenotype
- RNA Interference