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Mutations in yhiT enable utilization of exogenous pyrimidine intermediates in Salmonella enterica serovar Typhimurium.

Microbiology (Reading, England) - 1 Aug 2007

Zaharik Michelle L, Lamb Sherry S, Baker Kristian E, Krogan Nevan J, Neuhard Jan, Kelln Rod A

Abstract excerpt

Mutants capable of utilizing the pyrimidine biosynthetic intermediates carbamoylaspartate and dihydroorotate for growth were derived from pyrimidine auxotrophs of Salmonella enterica serovar Typhimurium LT2. The gain-of-function phenotypes both resulted from mutations in a single gene, yhiT, the...

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Identifiers

PMID: 17660412
DOI: 10.1099/mic.0.2007/007583-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17660412-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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