Article
Mutational analysis of active site residues essential for sensing of organic hydroperoxides by Bacillus subtilis OhrR.
Journal of bacteriology - 1 Oct 2007
Soonsanga Sumarin, Fuangthong Mayuree, Helmann John D
Abstract excerpt
Bacillus subtilis OhrR is the prototype for the one-Cys family of organic peroxide-sensing regulatory proteins. Mutational analyses indicate that the high sensitivity of the active site cysteine (C15) to peroxidation requires three Tyr residues. Y29 and Y40 from the opposing subunit of the functi...
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