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Article

Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage‐independent growth in human tonsil epithelial cells

26 Jul 2007

Abstract excerpt

BACKGROUND: Human papillomavirus 16 (HPV16) has been associated with head and neck squamous cell carcinoma (HNSCC) in up to 60% of sampled specimens. METHODS: To understand better the viral genes required to transform human tonsil epithelial cells (HTEC), we isolated HTEC's and transduced them with retroviral vectors containing HPV16 E6 and E7. RESULTS: Immortalization and anchorage-independent growth of HTEC's...

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PMID: 17657785
DOI: 10.1002/hed.20673

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