Engineering cartilage and bone using human mesenchymal stem cells

Abstract excerpt

Cartilage and bone defects are leading causes of disability. The economic burden of orthopedic repair exceeds 28 billion dollars per year in the United States alone,1 and the situation is similar in many other countries. Although artificial joints or metal inserts are widely utilized and in most cases work well, cell-based therapies based on tissue-engineered cartilage and bone beckon a new frontier for clinical...

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