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SP3 Represses the SP1-mediated Transactivation of the HumanCOL2A1 Gene in Primary and De-differentiated Chondrocytes

1 Oct 2001

Abstract excerpt

Sp1 and Sp3 effects on the transcription of the human alpha1(II) procollagen gene (COL2A1) were investigated in both differentiated and de-differentiated rabbit articular chondrocytes. Transient transfection with constructs of deleted COL2A1 promoter sequences driving the luciferase reporter gene revealed that the region spanning -266 to +121 base pairs showed Sp1-enhancing effects, whatever the differentiation...

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PMID: 11447232
DOI: 10.1074/jbc.m105083200

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SP3 Represses the SP1-mediated Transactivation of the HumanCOL2A1 Gene in Primary and De-differentiated ChondrocytesPMID 11447232Read ↗

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Positive regulation of human α1 (I) collagen promoter activity by transcription factor Sp1Semantic proximity Read ↗

Regulation of Human COL2A1 Gene Expression in ChondrocytesSemantic proximity Read ↗

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Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cellsSemantic proximity Read ↗

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