Article
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol.
European journal of pharmacology - 14 Nov 2007
Quintanilla María Elena, Bustamante Diego, Tampier Lutske, Israel Yedy, Herrera-Marschitz Mario
Abstract excerpt
Lower tissue levels of dopamine and 5-hydroxytryptamine (5-HT) have been found in the nucleus accumbens of alcohol-naïve rats selectively bred to prefer ethanol than in rats bred to avoid it. These findings have led to the hypothesis that differences in the dopamine and 5-HT tone may be linked to ethanol preference. In the present study we used the in vivo microdialysis technique to determine the actual...
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