Article
Transforming growth factor beta1 gene polymorphism 509C/T in deep infiltrating endometriosis.
Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2007
van Kaam K J A F, Romano A, Dunselman G A J, Groothuis P G
Abstract excerpt
Deep infiltrating endometriosis is characterized by the presence of nodular lesions largely composed of fibromuscular tissue. Transforming growth factor beta 1 (TGF-beta1) is the cytokine most causatively associated with disorders characterized by fibrosis throughout the body. Therefore, the hypothesis was tested that mechanisms increasing the fraction of biologically active TGF-beta1, such as TGF-beta 1 gene...
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