Article
Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism.
Clinical chemistry - 1 Aug 2007
Delanghe Joris R, Langlois Michel R, De Buyzere Marc L, Torck Mathieu A
Abstract excerpt
Ascorbic acid (vitamin C) is prone to oxidation in vivo. The human plasma protein haptoglobin (Hp) shows a genetic polymorphism with 3 major phenotypes (Hp 1-1, Hp 2-1, and Hp 2-2) that show important functional differences. Despite an adequate nutritional supply, in Hp 2-2 individuals (most common among Asian populations) vitamin C is markedly lower in concentration and particularly prone to oxidation in vivo....
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