Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA fingerprints provide direct evidence for the inhibitory role of TGFβ and PD-1 on CD4+ T cells in Hodgkin lymphoma

21 Jul 2007

Abstract excerpt

A hallmark of various human malignancies is the expression of immunoinhibitory factors within the tumor microenvironment. There is indirect evidence based on in vitro experiments that tumor-infiltrating T cells in human malignancies are suppressed by such factors. Still, direct evidence of the influence of individual inhibitory factors on immune cells in human cancer in vivo is lacking. To address this question,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to Lymphoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17644739
DOI: 10.1182/blood-2006-12-064360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA fingerprints provide direct evidence for the inhibitory role of TGFβ and PD-1 on CD4+ T cells in Hodgkin lymphomaPMID 17644739Read ↗

Single cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironmentSemantic proximity Read ↗

The Love-Hate Relationship Between TGF-β Signaling and the Immune System During Development and TumorigenesisSemantic proximity Read ↗

Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphomaSemantic proximity Read ↗

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphomaSemantic proximity Read ↗

A library of gene expression signatures to illuminate normal and pathological lymphoid biologySemantic proximity Read ↗

The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphomaSemantic proximity Read ↗

TGF-beta: a master immune regulatorSemantic proximity Read ↗

IL-10- and TGF-β-driven BCL6 expression suppresses antiviral defenses and renders lymph node T follicular helper cells permissive to HIV infectionSemantic proximity Read ↗

Mechanisms of Immune Evasion and Immune Modulation by Lymphoma CellsSemantic proximity Read ↗

TGFbeta-mediated activation of Smad1 in B-cell non-Hodgkin's lymphoma and effect on cell proliferation.Semantic proximity Read ↗

TGFβ shuts the door on T cellsSemantic proximity Read ↗

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.