Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma.

doi:10.1200/JCO.2017.74.3179

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Article

Tumor-Specific T-Cells Engineered to Overcome Tumor Immune Evasion Induce Clinical Responses in Patients With Relapsed Hodgkin Lymphoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Apr 2018

Bollard Catherine M, Tripic Tamara, Cruz Conrad Russell, Dotti Gianpietro, Gottschalk Stephen, Torrano Vicky, Dakhova Olga, Carrum George, Ramos Carlos A, Liu Hao, Wu Meng-Fen, Marcogliese Andrea N, Barese Cecilia, Zu Youli, Lee Daniel Y, O'Connor Owen, Gee Adrian P, Brenner Malcolm K, Heslop Helen E, Rooney Cliona M

Abstract excerpt

Purpose Transforming growth factor-β (TGF-β) production in the tumor microenvironment is a potent and ubiquitous tumor immune evasion mechanism that inhibits the expansion and function of tumor-directed responses; therefore, we conducted a clinical study to discover the effects of the forced expression of a dominant-negative TGF-β receptor type 2 (DNRII) on the safety, survival, and activity of infused...

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Identifiers

PMID: 29315015
DOI: 10.1200/JCO.2017.74.3179
PMCID: PMC5891126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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