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Article

Increased Expression of the Pro‐Protein Convertase Furin Predicts Decreased Survival in Ovarian Cancer

1 Jan 2007

Abstract excerpt

BACKGROUND: Proprotein convertases (PCs) are serine proteases that after restricted proteolysis activate many proteins that play a crucial role in cancer such as metalloproteinases, growth factors and growth factor receptors, adhesion molecules, and angiogenic factors. Although the expression of several PCs is increased in many tumors, their expression in primary ovarian tumors has not been studied in detail. We...

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PMID: 17641413
DOI: 10.1155/2007/930321

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