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Article

A c-di-GMP effector system controls cell adhesion by inside-out signaling and surface protein cleavage.

PLoS biology - 1 Feb 2011

Newell Peter D, Boyd Chelsea D, Sondermann Holger, O'Toole George A

Abstract excerpt

In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions, a c-di-GMP phosphodiesterase (PDE) RapA is expressed, depleting cellular c-di-GMP and causing the loss of a critical outer-membrane adhesin LapA from the cell surface. This response involves an...

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Source

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Identifiers

PMID: 21304920
DOI: 10.1371/journal.pbio.1000587
PMCID: PMC3032545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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