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Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses

20 Jul 2007

Abstract excerpt

Adenovirus type 5 (Ad5)-based vectors have been used in clinical trials for glioblastoma treatment, but the capacity of Ad5 to infect human glioma cells was questioned. Seeking to improve the adenovirus transduction, we tested four Ad5-based vectors differing only in their fiber gene on permanent and short-term cultures of glioblastoma cells. A wild-type fiber Ad5 vector (Ad5.Luc) was compared to an RGD...

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PMID: 17640083
DOI: 10.1002/jgm.1076

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