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Article

Lack of Association of the APOE ε4 Allele with the Risk of Obstructive Sleep Apnea: Meta-Analysis and Meta-Regression

1 Nov 2009

Abstract excerpt

STUDY OBJECTIVES: Reports on the association of polymorphisms in the gene encoding apolipoprotein E (APOE)--a vital macromolecule in cholesterol metabolism--with obstructive sleep apnea (OSA) have provided conflicting results. Our objective was to meta-analytically synthesize the existing evidence for the association of the APOE epsilon4 allele with the risk of OSA. DESIGN: Random effects meta-analysis and...

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PMID: 19928390
DOI: 10.1093/sleep/32.11.1507

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