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Epstein-Barr Virus Latent Nuclear Antigens Can Induce Metastasis in a Nude Mouse Model

19 Jul 2007

Abstract excerpt

Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus associated with the development of both lymphoid and epithelial tumors. The EBV critical latent antigens EBNA1 and EBNA3C interact with Nm23-H1, a known suppressor of cell migration and tumor metastasis. This interaction is critical for the regulation of downstream cellular genes involved in tumorigenesis and cell migration. The significance of these...

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PMID: 17634231
DOI: 10.1128/jvi.00886-07

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