Article
Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).
The American journal of tropical medicine and hygiene - 1 Jul 2007
Mayxay Mayfong, Nair Shalini, Sudimack Dan, Imwong Mallika, Tanomsing Naowarat, Pongvongsa Tiengkham, Phompida Samlane, Phetsouvanh Rattanaxay, White Nicholas J, Anderson Tim J C, Newton Paul N
Abstract excerpt
Molecular markers provide a rapid and relatively inexpensive approach for assessing antimalarial drug susceptibility. We collected 884 Plasmodium falciparum-infected blood samples from 17 Lao provinces. Each sample was genotyped for 11 codons in the chloroquine resistance transporter (pfcrt), dih...
Topics
- Adolescent
- Animals
- Antimalarials
- Drug Combinations
- Drug Resistance
- Female
- Humans
- Laos
- Malaria, Falciparum
- Male
- Mutation
- Plasmodium falciparum
- Protozoan Proteins
- Pyrimethamine