Article
Combined molecular and clinical assessment of Plasmodium falciparum antimalarial drug resistance in the Lao People's Democratic Republic (Laos).
The American journal of tropical medicine and hygiene - 1 Jul 2007
Mayxay Mayfong, Nair Shalini, Sudimack Dan, Imwong Mallika, Tanomsing Naowarat, Pongvongsa Tiengkham, Phompida Samlane, Phetsouvanh Rattanaxay, White Nicholas J, Anderson Tim J C, Newton Paul N
Abstract excerpt
Molecular markers provide a rapid and relatively inexpensive approach for assessing antimalarial drug susceptibility. We collected 884 Plasmodium falciparum-infected blood samples from 17 Lao provinces. Each sample was genotyped for 11 codons in the chloroquine resistance transporter (pfcrt), dihydrofolate reductase (pfdhfr), and dihydropteroate synthase (pfdhps) genes. The samples included 227 collected from...
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