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Article

Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss.

The American journal of pathology - 1 Aug 2007

Guipponi Michel, Tan Justin, Cannon Ping Z F, Donley Lauren, Crewther Pauline, Clarke Maria, Wu Qingyu, Shepherd Robert K, Scott Hamish S

Abstract excerpt

Defective proteolysis has been implicated in hearing loss through the discovery of mutations causing autosomal recessive nonsyndromic deafness in a type II transmembrane serine protease gene, TMPRSS3. To investigate their physiological function and the contribution of this family of proteases to the auditory function, we analyzed the hearing status of mice deficient for hepsin, also known as TMPRSS1. These mice...

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Identifiers

PMID: 17620368
DOI: 10.2353/ajpath.2007.070068
PMCID: PMC1934525

Genes

TMPRSS3

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