Accurate determination of mean cell volume by isotope dilution in erythrocyte populations with variable deformability.

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Article

Accurate determination of mean cell volume by isotope dilution in erythrocyte populations with variable deformability.

Blood cells - 1 Jan 1991

Marvel J S, Sutera S P, Krogstad D J, Zarkowsky H S, Williamson J R

Abstract excerpt

Variations in erythrocyte deformability and morphology lead to artifacts in electronic determinations of mean cellular volume (MCV) by the aperture-impedance method. The micropipette-aspiration technique loses accuracy when applied to severely aberrant cells such as dense sickle cells. A new light-scattering technique requires that the cells be capable of undergoing isovolumetric sphering. In contrast, the...

Topics

Anemia, Sickle Cell
Animals
Cattle
Cobalt Radioisotopes
Edetic Acid
Erythrocyte Deformability
Erythrocyte Indices
Genetic Variation
Humans
Iodine Radioisotopes
Microspheres

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Radioisotope Dilution Technique

Rats

Reference Values

Rheology

Serum Albumin, Bovine

Sheep

Source

Open in PubMed

Identifiers

PMID: 1760558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1760558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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