Article
Demonstration of circulating allergen-specific CD4+CD25highFoxp3+ T-regulatory cells in both nonatopic and atopic individuals.
The Journal of allergy and clinical immunology - 1 Aug 2007
Maggi Laura, Santarlasci Veronica, Liotta Francesco, Frosali Francesca, Angeli Roberta, Cosmi Lorenzo, Maggi Enrico, Romagnani Sergio, Annunziato Francesco
Abstract excerpt
BACKGROUND: CD4(+)CD25(+)Foxp3(+) T-regulatory (Treg) cells play a fundamental role in the control of autoimmunity. Whether human CD4(+)CD25(+)Foxp3(+) Treg cells that recognize foreign antigens also exist is less clear. OBJECTIVE: To investigate the existence in humans of circulating Treg cells able to recognize exogenous antigens, including allergens. METHODS: CD4(+)CD25(high)Foxp3(+) and CD4(+)CD25(-)Foxp3(-)...
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