Article
Switch recombination in fetal porcine thymus is uncoupled from somatic mutation.
Veterinary immunology and immunopathology - 10 Sept 2002
Butler J E, Sun J, Weber P, Ford S P, Rehakova Z, Sinkora J, Francis David, Lager K
Abstract excerpt
Since fetal serum Ig isotype profiles suggested that IgG and IgA could be of de novo origin, we studied their transcription and secretion. IgM transcripts were present at 50 days of gestation in major fetal lymphoid tissues, IgG and IgA transcription was pronounced at 60 days in fetal thymus and both transcription and secretion in this organ increased in late fetal life. The CDR3 spectratype of thymic IgG and IgA...
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