Article
A molecular basis for natural selection at the timeless locus in Drosophila melanogaster.
Science (New York, N.Y.) - 29 Jun 2007
Sandrelli Federica, Tauber Eran, Pegoraro Mirko, Mazzotta Gabriella, Cisotto Paola, Landskron Johannes, Stanewsky Ralf, Piccin Alberto, Rosato Ezio, Zordan Mauro, Costa Rodolfo, Kyriacou Charalambos P
Abstract excerpt
Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly because it enhances diapause. We show that the mutant allele attenuates the photosensitivity of the circadian clock and...
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