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Article

A molecular basis for natural selection at the timeless locus in Drosophila melanogaster.

Science (New York, N.Y.) - 29 Jun 2007

Sandrelli Federica, Tauber Eran, Pegoraro Mirko, Mazzotta Gabriella, Cisotto Paola, Landskron Johannes, Stanewsky Ralf, Piccin Alberto, Rosato Ezio, Zordan Mauro, Costa Rodolfo, Kyriacou Charalambos P

Abstract excerpt

Diapause is a protective response to unfavorable environments that results in a suspension of insect development and is most often associated with the onset of winter. The ls-tim mutation in the Drosophila melanogaster clock gene timeless has spread in Europe over the past 10,000 years, possibly...

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Source

Identifiers

PMID: 17600216
DOI: 10.1126/science.1138426

Genes

TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17600216-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular basis for natural selection at the timeless locus in Drosophila melanogaster.PMID 17600216Read ↗

Natural selection favors a newly derived timeless allele in Drosophila melanogaster.Semantic proximity Read ↗

A natural <i>timeless</i> polymorphism allowing circadian clock synchronization in ‘white nights’Semantic proximity Read ↗

Adaptation of Drosophila melanogaster to Long Photoperiods of High-Latitude Summers Is Facilitated by the ls-Timeless Allele.Semantic proximity Read ↗

Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock.Semantic proximity Read ↗

Geographical analysis of diapause inducibility in European Drosophila melanogaster populations.Semantic proximity Read ↗

Association between circadian clock genes and diapause incidence in Drosophila triauraria.Semantic proximity Read ↗

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.Semantic proximity Read ↗

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.Semantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

A genome-wide association study implicates the olfactory system in Drosophila melanogaster diapause-associated lifespan extension and fecundity.Semantic proximity Read ↗

Photosensitive Alternative Splicing of the Circadian Clock Gene timeless Is Population Specific in a Cold-Adapted Fly, Drosophila montana.Semantic proximity Read ↗

Flies, clocks and evolution.Semantic proximity Read ↗

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