Article
The A/T1381 polymorphism in the A1-domain of von Willebrand factor influences the affinity of von Willebrand factor for platelet glycoprotein Ibalpha.
Thrombosis and haemostasis - 1 Jul 2007
Szántó Tímea, Schlammadinger Agota, Staelens Stephanie, De Meyer Simon F, Freson Kathleen, Pareyn Inge, Vauterin Stephan, Hársfalvi Jolán, Deckmyn Hans, Vanhoorelbeke Karen
Abstract excerpt
Many polymorphisms in vonWillebrand factor (VWF) have been reported and their association with VWF plasma levels or cardiovascular diseases has been investigated. The aim of this study was to examine whether the amino acid polymorphism A/T1381 in the VWF A1-domain would affect VWF binding to platelet GPIbalpha. Sixty-one normal individuals were genotyped at the A/T1381 locus. Twenty-one A/A1381 homozygotes, 30...
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