Article
Critical von Willebrand factor A1 domain residues influence type VI collagen binding.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2012
Flood V H, Gill J C, Christopherson P A, Bellissimo D B, Friedman K D, Haberichter S L, Lentz S R, Montgomery R R
Abstract excerpt
BACKGROUND: von Willebrand factor (VWF) binds to subendothelial collagen at sites of vascular injury. Laboratory testing for von Willebrand disease (VWD), however, does not always include collagen binding assays (VWF:CB) and standard VWF:CB assays use type I and/or type III collagen rather than type VI collagen. OBJECTIVES: We report here on several mutations that exclusively alter binding to type VI collagen....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.