Article
Frequency of EGFR and KRAS mutations in Japanese patients with lung adenocarcinoma with features of the mucinous subtype of bronchioloalveolar carcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2010
Hata Akito, Katakami Nobuyuki, Fujita Shiro, Kaji Reiko, Imai Yukihiro, Takahashi Yutaka, Nishimura Takashi, Tomii Keisuke, Ishihara Kyosuke
Abstract excerpt
INTRODUCTION: Adenocarcinoma of the lung, especially bronchioloalveolar carcinoma (BAC) and adenocarcinoma with BAC features (AWBF), is potentially sensitive to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs); however, the efficacy seems to differ between the histologic subtypes. Mucinous BAC and AWBF (MBAC/AWBF) are not particularly responsive to EGFR-TKIs compared with nonmucinous...
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