Article
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Nature structural & molecular biology - 1 Jul 2007
Corsini Lorenzo, Bonnal Sophie, Bonna Sophie, Basquin Jerome, Hothorn Michael, Scheffzek Klaus, Valcárcel Juan, Sattler Michael
Abstract excerpt
The U2AF-homology motif (UHM) mediates protein-protein interactions between factors involved in constitutive RNA splicing. Here we report that the splicing factor SPF45 regulates alternative splicing of the apoptosis regulatory gene FAS (also called CD95). The SPF45 UHM is necessary for this activity and binds UHM-ligand motifs (ULMs) present in the 3' splice site-recognizing factors U2AF65, SF1 and SF3b155. We...
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