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Article

FBXW7 and DNA copy number instability.

Breast cancer research and treatment - 1 May 2008

Byrd Kristin N, Huey Bing, Roydasgupta Ritu, Fridlyand Jane, Snijders Antoine M, Albertson Donna G

Abstract excerpt

SKP1-cullin-F-box protein (SCF) type ubiquitin ligases degrade proteins controlling the G1/S transition. Deficiency for FBXW7 (also known as hCDC4), which encodes the F-box protein of the SCF type ubiquitin ligase is associated with genomic instability. Here, we investigated the association of FBXW7 deficiency with chromosomal instability in breast cancer. We screened 49 tumors previously profiled by array CGH...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17588203
DOI: 10.1007/s10549-007-9623-7

Genes

SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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