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Article

Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS.

The Journal of investigative dermatology - 1 Dec 2007

Lu Hong, Chen Jian, Planko Laura, Zigrino Paola, Klein-Hitpass Ludger, Magin Thomas M

Abstract excerpt

Epidermolysis bullosa simplex (EBS) is a skin disorder caused by mutations in keratin (K) 5 or K14 genes. It is widely regarded as a mechanobullous disease, resulting from a weakened cytoskeleton, causing extensive cytolysis. It was postulated by others that certain K14 mutations induce tumor necrosis factor-alpha (TNF-alpha) and increase apoptosis. Here, we report that in K5-/- mice and in a cell culture model...

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Source

Identifiers

PMID: 17581617
DOI: 10.1038/sj.jid.5700918

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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