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Article

Clustering suicidal phenotypes and genetic associations with brain-derived neurotrophic factor in patients with substance use disorders.

Translational psychiatry - 21 Jan 2021

Icick Romain, Bloch Vanessa, Prince Nathalie, Karsinti Emily, Lépine Jean-Pierre, Laplanche Jean-Louis, Mouly Stéphane, Marie-Claire Cynthia, Brousse Georges, Bellivier Frank, Vorspan Florence

Abstract excerpt

Suicide attempts (SA), especially recurrent SA or serious SA, are common in substance use disorders (SUD). However, the genetic component of SA in SUD samples remains unclear. Brain-derived neurotrophic factor (BDNF) alleles and levels have been repeatedly involved in stress-related psychopathology. This investigation uses a within-cases study of BDNF and associated factors in three suicidal phenotypes ('any',...

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Identifiers

PMID: 33479229
DOI: 10.1038/s41398-021-01200-5
PMCID: PMC7820499

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