Article
Predictive genotypic algorithm for virologic response to lopinavir-ritonavir in protease inhibitor-experienced patients.
Antimicrobial agents and chemotherapy - 1 Sept 2007
King Martin S, Rode Richard, Cohen-Codar Isabelle, Calvez Vincent, Marcelin Anne-Geneviève, Hanna George J, Kempf Dale J
Abstract excerpt
Several genotypic resistance algorithms have been proposed for quantitation of the degree of phenotypic resistance to the human immunodeficiency virus (HIV) protease inhibitor (PI) lopinavir (LPV), including the original LPV mutation score. In this study, we retrospectively evaluated 21 codons in HIV protease known to be associated with PI resistance in a large antiretroviral agent-experienced observational...
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