Article
The association between endothelin-1 gene polymorphisms and susceptibility to vitiligo in a Korean population.
Experimental dermatology - 1 Jul 2007
Kim Hyun-Jin, Choi Chun-Pill, Uhm Yoon Kyung, Kim Young Il, Lee Jin-Woo, Yoon Seo Hyun, Chung Joo-Ho, Lee Mu-Hyoung
Abstract excerpt
BACKGROUND: Vitiligo is a skin disorder affected by genetic, environmental, local and endocrine factors. Endothelin-1, which is expressed by keratinocytes, has paracrine effects on melanocytes, influencing their homeostasis, proliferation and pigmentation. It is thought to play a role in the skin response to 311-nm, narrow-band ultraviolet irradiation. OBJECTIVE: To investigate the association of endothelin-1...
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