Article
Protective association of TIM1-1454G>a polymorphism with asthma in a North Indian population.
Lung - 1 Feb 2015
Sinha Shweta, Singh Jagtar, Jindal Surinder Kumar
Abstract excerpt
PURPOSE: TIM1 is a key regulator of Th2-dominated immune responses, including allergy, asthma, autoimmunity, and response to the pathogens. They are mainly expressed by hepatocytes and lymphoid cells. Analysis of the sequence of TIM1 was found to have range of SNPs which increases the transcriptional activity of the TIM1 gene. METHODS: A case-control study was conducted with a total of 964 subjects, including 483...
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