Article
Two polymorphisms in the TIM-4 gene are associated with asthma in a Chinese Han population.
International journal of immunogenetics - 1 Feb 2011
Zhao B, Abdelmoudjib G, Li J, Li H, Wei C, Gong Y, Liu Q
Abstract excerpt
The gene family of the T cell immunoglobulin and mucin domain (TIM) proteins encodes cell surface receptors that are involved in the regulation of Th1- and Th2-cell-mediated immunity. TIM-1 gene has been found to be associated with asthma in several populations. TIM-4, the natural ligand for TIM-1, may influence the susceptility to asthma.To investigate the association of the TIM-4 gene polymorphisms with asthma...
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