Article
Family-based association study of Tim-1 and Tim-3 gene polymorphisms with childhood asthma in Chinese trios.
International archives of allergy and immunology - 1 Jan 2009
Wu Qi-Wen, Cai Peng-Cheng, Wang Ling, Li Yi-Rong, Kong Ling-Ling, Hu Li-Hua
Abstract excerpt
BACKGROUND: Asthma is a complex genetic disease, caused by the interaction of multiple genetic and environmental factors. T cell immunoglobulin domain and mucin domain (Tim) genes are located in chromosome 5q31-33, a region repeatedly linked to asthma or asthma-related phenotypes in several populations. Two members of Tim families, Tim-1 and Tim-3, which are expressed on T cell surface and potentially involved in...
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