Article
Association of ICAM3 genetic variant with severe acute respiratory syndrome.
The Journal of infectious diseases - 15 Jul 2007
Chan Kelvin Y K, Ching Johannes C Y, Xu M S, Cheung Annie N Y, Yip Shea-Ping, Yam Loretta Y C, Lai Sik-To, Chu Chung-Ming, Wong Andrew T Y, Song You-Qiang, Huang Fang-Ping, Liu Wei, Chung P H, Leung G M, Chow Eudora Y D, Chan Eric Y T, Chan Jane C K, Ngan Hextan Y S, Tam Paul, Chan Li-Chong, Sham Pak, Chan Vera S F, Peiris Malik, Lin Steve C L, Khoo Ui-Soon
Abstract excerpt
Genetic polymorphisms have been demonstrated to be associated with vulnerability to human infection. ICAM3, an intercellular adhesion molecule important for T cell activation, and FCER2 (CD23), an immune response gene, both located on chromosome 19p13.3, were investigated for host genetic susceptibility and association with clinical outcome. A case-control study based on 817 patients with confirmed severe acute...
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