Article
E-selectin S128R polymorphism leads to severe asthma.
Iranian journal of allergy, asthma, and immunology - 1 Jun 2007
Nadi Ebrahim, Hajilooi Mehrdad, Zeraati Fatemeh, Ansari Mostafa, Tavana Sasan, Hashemi Sayed Hamid, Rafiei Alireza
Abstract excerpt
The E-selectin mediates the interaction of activated endothelial cells with leukocytes and plays a fundamental role in the pathogenesis of asthma. It has been suggested that an S/R (Serine128Arginine) polymorphism of E-selectin alters ligand binding function. Our purpose in this study was to dete...
Topics
- Adolescent
- Adult
- Arginine
- Asthma
- Case-Control Studies
- E-Selectin
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Male
- Middle Aged