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Article

SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes.

Molecular and cellular biology - 1 Aug 2007

Sautel Céline F, Cannella Dominique, Bastien Olivier, Kieffer Sylvie, Aldebert Delphine, Garin Jérôme, Tardieux Isabelle, Belrhali Hassan, Hakimi Mohamed-Ali

Abstract excerpt

Posttranslational histone modifications modulate chromatin-templated processes in various biological systems. H4K20 methylation is considered to have an evolutionarily ancient role in DNA repair and genome integrity, while its function in heterochromatin function and gene expression is thought to have arisen later during evolution. Here, we identify and characterize H4K20 methylases of the Set8 family in...

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Identifiers

PMID: 17562855
DOI: 10.1128/MCB.00482-07
PMCID: PMC1952134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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