Article
The secreted cell signal Folded Gastrulation regulates glial morphogenesis and axon guidance in Drosophila.
Developmental biology - 1 Aug 2007
Ratnaparkhi Anuradha, Zinn Kai
Abstract excerpt
During gastrulation in Drosophila, ventral cells change shape, undergoing synchronous apical constriction, to create the ventral furrow (VF). This process is affected in mutant embryos lacking zygotic function of the folded gastrulation (fog) gene, which encodes a putative secreted protein. Fog is an essential autocrine signal that induces cytoskeletal changes in invaginating VF cells. Here we show that Fog is...
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