Article
Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population.
Cancer - 15 Jul 2007
Minegishi Yuji, Tsukino Hiromasa, Muto Manabu, Goto Koichi, Gemma Akihiko, Tsugane Shoichiro, Kudoh Shoji, Nishiwaki Yutaka, Esumi Hiroyasu
Abstract excerpt
BACKGROUND: It is believed that acetaldehyde plays an important role in alcohol-related carcinogenesis; although current epidemiologic studies have provided inconsistent findings on the association between alcohol consumption and the risk of lung cancer. METHODS: To clarify the hypothesis that genetic polymorphisms in alcohol-metabolizing enzymes may influence susceptibility to lung cancer, the authors conducted...
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