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Article

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis.

Journal of translational medicine - 7 Jun 2007

Chamian Francesca, Lin Shao-Lee, Lee Edmund, Kikuchi Toyoko, Gilleaudeau Patricia, Sullivan-Whalen Mary, Cardinale Irma, Khatcherian Artemis, Novitskaya Inna, Wittkowski Knut M, Krueger James G, Lowes Michelle A

Abstract excerpt

BACKGROUND: Alefacept (anti-CD2) biological therapy selectively targets effector memory T cells (Tem) in psoriasis vulgaris, a model Type 1 autoimmune disease. METHODS: Circulating leukocytes were phenotyped in patients receiving alefacept for moderate to severe psoriasis. RESULTS: In all patients, this treatment caused a preferential decrease in effector memory T cells (CCR7- CD45RA-) (mean 63% reduction) for...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17555598
DOI: 10.1186/1479-5876-5-27
PMCID: PMC1906741

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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