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Apoptosis and Pathogenesis of Avian Influenza A (H5N1) Virus in Humans

1 May 2007

Abstract excerpt

The pathogenesis of avian influenza A (H5N1) virus in humans has not been clearly elucidated. Apoptosis may also play an important role. We studied autopsy specimens from 2 patients who died of infection with this virus. Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. Numerous apoptotic leukocytes were observed in the lung of a patient who died...

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PMID: 17553248
DOI: 10.3201/eid1305.060572

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