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Apoptosis: a mechanism of cell killing by influenza A and B viruses

1 Jun 1994

Abstract excerpt

In previous studies, we observed that the virulent avian influenza A virus A/Turkey/Ontario/7732/66 (Ty/Ont) induced severe lymphoid depletion in vivo and rapidly killed an avian lymphocyte cell line (RP9) in vitro. In examining the mechanism of cell killing by this virus, we found that Ty/Ont induced fragmentation of the RP9 cellular DNA into a 200-bp ladder and caused ultrastructural changes characteristic of...

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PMID: 8189504
DOI: 10.1128/jvi.68.6.3667-3673.1994

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