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Article

Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegans

5 Jun 2007

Abstract excerpt

BACKGROUND: The prolonged time course of Huntington's disease (HD) neurodegeneration increases both the time and cost of testing potential therapeutic compounds in mammalian models. An alternative is to initially assess the efficacy of compounds in invertebrate models, reducing time of testing from months to days. METHODOLOGY/PRINCIPAL FINDINGS: We screened candidate therapeutic compounds that were identified...

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PMID: 17551584
DOI: 10.1371/journal.pone.0000504

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