Article
Aggressive systemic mastocytosis after germ cell tumor of the ovary: C-KIT mutation documentation in both disease states.
Journal of pediatric hematology/oncology - 1 Jun 2007
Lee Jae Wook, Yang Woo Sik, Chung Seung Yun, Kang Jin Han, Cho Bin, Kim Hack Ki, Kim Kyoung Mee, Jeong Dae Chul
Abstract excerpt
We report a case of aggressive systemic mastocytosis in a 3-year-old girl, who had undergone treatment for ovarian germ cell tumor during the previous 8 months. On diagnosis of systemic mastocytosis, she was treated with interferon-alpha and steroids. She showed tolerable side effects of interferon-alpha infusion, but died of multiple organ failure after 2 months of treatment. Point mutations of the C-KIT gene,...
Topics
- Bone Marrow
- Child, Preschool
- DNA Primers
- Female
- Humans
- Mastocytosis, Systemic
- Mutation
- Neoplasms, Germ Cell and Embryonal
- Ovarian Neoplasms
- Polymerase Chain Reaction
- Proto-Oncogene Proteins c-kit