Identification and Characterization of<i>CPS1</i>as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of<i>Cryptococcus neoformans</i>Infection

Abstract excerpt

Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer cell wall. In this report, we investigate the function of the CPS1 gene and its pathogenesis. We demonstrated that treatment of yeast with either 4-methylumbelliferone or...

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