Article
Prophylactic mastectomy in BRCA1/2 mutation carriers and women at risk of hereditary breast cancer: long-term experiences at the Rotterdam Family Cancer Clinic.
Annals of surgical oncology - 1 Dec 2007
Heemskerk-Gerritsen Bernadette A M, Brekelmans Cecile T M, Menke-Pluymers Marian B E, van Geel Albert N, Tilanus-Linthorst Madeleine M A, Bartels Carina C M, Tan Murly, Meijers-Heijboer Hanne E J, Klijn Jan G M, Seynaeve Caroline
Abstract excerpt
BACKGROUND: BRCA1/2 mutation carriers and women from a hereditary breast(/ovarian) cancer family have a highly increased risk of developing breast cancer (BC). Prophylactic mastectomy (PM) results in the greatest BC risk reduction. Long-term data on the efficacy and sequels of PM are scarce. METHODS: From 358 high-risk women (including 236 BRCA1/2 carriers) undergoing PM between 1994 and 2004, relevant data on...
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