Article
The hotei mutation of medaka in the anti-Mullerian hormone receptor causes the dysregulation of germ cell and sexual development.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007
Morinaga Chikako, Saito Daisuke, Nakamura Shuhei, Sasaki Takashi, Asakawa Shuichi, Shimizu Nobuyoshi, Mitani Hiroshi, Furutani-Seiki Makoto, Tanaka Minoru, Kondoh Hisato
Abstract excerpt
We previously performed mutant screens in the medaka for defects in gonadal development and identified a mutant of interest in this regard, which was designated as hotei (hot). This mutant manifests a number of remarkable phenotypic abnormalities including: (i) excessive proliferation of germ cells that initiates at around the hatching stage regardless of the genetic sex of the fish; (ii) initiation of premature...
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